Platinum Cured Silicone Tubing
Platinum addition silicone tubing contains no phthalate plasticizers associated with other types of tubing and is manufactured totally free from animal derived components. Our range of silicone tubing is biocompatible to the ISO 10993 standard and meets fully USP Class VI, FDA, NSF and European Pharmacopoeia criteria.
This range is manufactured in a dedicated "Platinum facility" (class FED 209E Class 10,000 clean room), which is completely clear of 2,4DCBA (dichlorobenzoyl Acid) residues (products found in peroxide cured silicone tubing)
Peroxide Cured Tube
Initially popular as a low cost alternative to platinum cured tube, the use of peroxide tubing in biopharmaceutical industry has largely been phased out due to the presence of toxic by products formed during the curing process of this material. Typical by -products found in peroxide (2,4-dichlorobenzoyl peroxide) cured tube include:
- 2,4-dichlorobenzoic acid dichlorobenzoic acid
- dichlorobenzoic acid methyl ester dichlorobenzoyl chloride
- dichlorobenzaldehyde trichlorobenzene
- chlorinated aliphatics polychlorinated biphenyls (PCBs)
- phenol, benzyl alcohol
- dichlorobenzene, dichlorophenol
Washing of peroxide cured tube with pure water (WFI) to remove these contaminants is largely ineffective as these and other by products continually leach from the silicone rubber matrix, concentrating at the tube surfaces, a process that is exacerbated by autoclaving.
Platinum Cured Tube
Platinum-catalysed addition curing is a faster process than peroxide curing which involves just one controlled reaction and which produces no undesirable by-products. For this reason platinum cured silicone tube is now the tube of choice for biopharmaceutical applications.
Care should however still be taken in the selection of your source of platinum tube, as only tube that has been manufactured in a completely dedicated "Platinum facility" using dedicated extrusion equipment and curing ovens etc, will be completely free of the peroxide decomposition derivatives from the peroxide curing process.
SA 450/60 platinum Silicone tube available from Cellon is manufactured in a dedicated "Platinum facility" (class FED 209E Class 10,000 clean room), which is completely clear of 2,4DCBA (dichlorobenzoyl Acid) residues.