For contract research organisations (CROs) and contract manufacturing organisations (CMOs), laboratory and manufacturing space is always at a premium. With its compact design, the Quorus bioprocessing platform sets the benchmark for flexibility combined with multi-functionality into a small footprint. This translates into greater efficiency and productivity at lower operating costs. As a next-generation bioprocessing control platform, the Quorus Single Use Bioreactors are available for the cultivation of microbial or mammalian adherent cell lines.
The Quorus microbial bioreactor platform has fully functional single-use capabilities optimised for continuous bioprocessing. It is specifically designed to facilitate bioprospecting of novel bioactive molecules. This occurs through the degradation of secondary metabolite expression in adherent cell lines.
True manufacturing on demand (MOD) capabilities are supported while
Stringent critical quality attributes (CQA) for the production of safe biologics are met
Quorus 3-D perfusion cell culture platform :
Optimisation of cell culture parameters is an essential component of process development for the production of active biopharmaceuticals, vaccines, and monoclonal antibodies (mAbs).
To achieve this, our proprietary transverse-flow membrane bioreactor, in combination with our customised biomimetic structural and functional surface modalities, simulates in vivo 3-D cell culture environments. These environments support and enhance cell attachment, propagation, higher cell densities, and scalability.
Designed as a transverse-flow membrane (TVFM) bioreactor, gas-liquid and liquid-liquid mass transfer is facilitated without the dispersion of one phase within another. Through the separation of fluid paths using specialised porous ceramic membranes, pressure differentials drive the mass transfer across gas-liquid or liquid-liquid phases. This facilitates larger shell-side mass transfer coefficients with minimal flow channelling which allows for modular scale-up characteristics and more precise performance prediction.
Configuration benefits :
- Models the mammalian circulatory system for in-vivo-like conditions
- Improves cell viability
- Eliminates the need to split cells (cell passage)
- Enables high density cell growth (the human body)
- Stabilises the pH of the cell culture system
- Reduces serum requirements and allows for non-serum medium
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